Dendrite labeled arbor model12/16/2023 ![]() Sholl analysis connectivity dendrite morphology root angle.Ĭopyright © 2019 The Author(s). The first two measures are determined by axon location and hence microcircuit structure the third arises from optimal wiring and represents a branching statistic estimating the need for conduction speed in a neuron. Quantitative analysis of thick fiber arbor features showed little difference between the sides, although contralateral boutons were significantly larger than ipsilateral ones. We find that the Sholl intersection profiles of most neurons can be reproduced from three basic, functional measures: the domain spanned by the dendritic arbor, the total length of the dendrite, and the angular distribution of how far dendritic segments deviate from a direct path to the soma (i.e., the root angle distribution). This in vitro model revealed that a number of morphological features of a developing dendritic arbor could be modified significantly by the presence of astrocytes, including the orientation of filopodia and dendritic branches, the extent of dendritic outgrowth, and locally restricted outgrowth based on contact with an individual astrocyte. Two distinct developmental models could explain subcellular synaptic specificity. Most labeled fibers were thick and they branched extensively to form distinctive terminal arbors decorated with numerous boutons that varied in size and shape. The Sholl intersection profile is obtained by counting the number of dendritic branches at a given distance from the soma and is a key measure of dendritic complexity it has applications from evaluating the changes in structure induced by pathologies to estimating the expected number of anatomical synaptic contacts. Author Summary Building a complex dendritic arbor requires tremendous cellular growth, and how membrane and protein components are transported to support a rapidly growing, polarized dendrite remains unclear. Sholl analysis has been an important technique in dendritic anatomy for more than 60 years. Sholl analysis has been an important technique in dendritic anatomy for more than 60 years. ![]()
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